Reproducibility of radiomics for deciphering tumor phenotype with imaging. The https:// ensures that you are connecting to the 44, e559e565. People without The .gov means its official. Use the Previous and Next buttons to navigate the slides or the slide controller buttons at the end to navigate through each slide. CT radiomics to predict Deauville score 4 positive and negative Hodgkin lymphoma manifestations. Paper should be a substantial original Article that involves several techniques or approaches, provides an outlook for We want to hear from you. Bull. Laura J. Jensen. Hasenclever, D.; Kurch, L.; Mauz-Krholz, C.; Elsner, A.; Georgi, T.; Wallace, H.; Landman-Parker, J.; Moryl-Bujakowska, A.; Cepelov, M.; Karln, J.; et al. Details of the patients are summarized in Table 1. Four of these features overlapped: mean, median, RMS, and 90th percentile. The number of patients with an unfavorable iPET response given the respective cutoffs was more than 4 times higher with the Deauville score (45.3%; 270/596) than with the SUV max approach (10.4%; 62/596). ; visualization, S.N.N., L.J.J. PET Clin. However, NCCN imaging guidelines for lymphoma surveillance state that it is acceptable to perform chest radiography or CT of the chest every six to 12 months for the first two years and then yearly for the next three to five years posttreatment.41 Surveillance imaging with PET-CT scans following complete remission is not recommended.40,41 Disease marker research is ongoing, examining minimal residual disease measurements, a polymerase chain reactionbased method that looks at identifying tumor-specific DNA sequences.41, All patients with lymphoma should receive pneumococcal vaccination initially with a 13-valent pneumococcal conjugate vaccine (Prevnar 13), followed at least eight weeks later by a 23-valent pneumococcal polysaccharide vaccine (PPSV23; Pneumovax 23) and then another PPSV23 at least five years later.44 Patients receiving antiB-cell antibodies should not receive annual influenza vaccination, and administration of live vaccines is contraindicated during chemotherapy. Scores of 1 and 2 are considered to be negative and 4 and 5 are considered to be positive. However, a clear tendency towards one texture feature or feature class that distinctly correlates with increased FDG uptake has not emerged yet. Target lesions were classified as Deauville score 4 positive (DS4+) or negative (DS4) based on their SUVpeak and then segmented in NECT images. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Score 3 should be interpreted according to the clinical context but in many Hodgkin Lymphoma patients indicates a good This site needs JavaScript to work properly. Radiomics of CT features may be nonreproducible and redundant: Influence of CT acquisition parameters. ; Kamal, N.M.; Elbehedy, R.; Hassan, T.H. 27, 10121020. Correspondence to Unauthorized use of these marks is strictly prohibited. Dr. Julian Rogasch is participant in the BIH-Charit Digital Clinician Scientist Program funded by the Charit Universittsmedizin Berlin, the Berlin Institute of Health, and the German Research Foundation (DFG). Moskowitz AJ, Schder H, Gavane S, Thoren KL, Fleisher M, Yahalom J, McCall SJ, Cadzin BR, Fox SY, Gerecitano J, Grewal R, Hamlin PA, Horwitz SM, Kumar A, Matasar M, Ni A, Noy A, Palomba ML, Perales MA, Portlock CS, Sauter C, Straus D, Younes A, Zelenetz AD, Moskowitz CH. 48, 7681. The Deauville 5-point scoring system is an internationally accepted and utilized five-point scoring system for the fluorodeoxyglucose (FDG) avidity of a Hodgkin lymphoma or Non-Hodgkin lymphoma tumor mass as seen on FDG positron emission tomography: 14, 749762. Radiomic features were extracted using PyRadiomics (Version 3.0)25,26, following the instructions of the Image Biomarker Standardisation Initiative (IBSI)27. Statistical analysis was performed using R (version 4.2.1, R Foundation for Statistical Computing)28. 2022 Nov 1;14(21):5390. doi: 10.3390/cancers14215390. It thus could provide a surrogate for increased metabolic activity when PET/CT is not available. All PET-CT parameters were strongly associated with the Deauville score (P<.001) and FFP (P<.0001) on univariate analysis. PET/CT, however, is time-consuming, cost-extensive, linked to high radiation and has a low availability. If not otherwise stated, the reading by S.N.N. Nucl. Lancet Oncol. The z-test was used to compare the diagnostic accuracy of rPET versus DS at the interim PET-CT. Of the 52 patients, 46 (88.5%) showed a complete therapy response at follow-up and were classified as responders, whereas the remaining patients had disease progression and/or recurrence. The diagnosis of lymphoma is made using an open lymph node biopsy, based off morphology, immunohistochemistry, and flow cytometry. 22, 3539. SUV max reduction (SUV max) and tumor/liver ratio (TLr) are promising tools for response assessment in lymphoma.We determined the optimal cutoff values for SUV max and TLr and Knogler, T., El-Rabadi, K., Weber, M., Karanikas, G. & Mayerhoefer, M. E. Three-dimensional texture analysis of contrast enhanced CT images for treatment response assessment in Hodgkin lymphoma: Comparison with F-18-FDG PET. False-positive patients showed evidence of disease at interim PET-CT imaging but remained in remission during follow-up. MeSH We decided to analyze NECTs obtained for the PET attenuation correction. PMC receives grants for the Department of Radiology fromActelion Pharmaceuticals, Bayer Schering, Bayer Vital, Bristol-Myers Squibb, Charit Research Organisation GmbH, Abbot, BRACCO Group, Deutsche Krebshilfe, Essex Pharma, Guerbet, INC Research, InSightec Ud, IPSEN Pharma, Kendlel MorphoSys AG, Lilly GmbH, MeVis Medical Solutions AG, Nexus Oncology, Novartis, Parexel Clinical Research Organisation Service, Pfizer GmbH, Philipps, Sanofis-Aventis, Siemens, Teruma Medical Corporation, Toshiba, Zukunfsfond Berlin, Amgen, AO Foundation, BARD, BBraun, Boehring Ingelheimer, Brainsgate, CELLACT Pharma, CeloNova Bio-Sciences, North Carolina GlaxoSmithKline Foundation, Jansen, Roehe, Sehumaeher GmbH, Medtronic, Pluristem, Quintiles, Astellas, Chiltern, Respicardia, TEVA, Abbvie, AstraZeneca, Galmed Research and Development. HL is often curable by conventional chemotherapy and radiotherapy. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. A score of 4 or 5 is an indicator to consider escalating therapy. J Clin Oncol. Defining a Hodgkin lymphoma population for novel therapeutics after relapse from autologous hematopoietic cell transplant. Image Biomarker Standardisation Initiative, Minimum redundancy maximum relevance with selection of 10 features, Minimum redundancy maximum relevance with selection of 20 features. Diagnostic value of baseline 18FDG PET/CT skeletal textural features in follicular lymphoma, Comparison of different automatic methods for the delineation of the total metabolic tumor volume in III stage Hodgkin Lymphoma, A PET Radiomics Model to Predict Refractory Mediastinal Hodgkin Lymphoma, Comparison of whole-body MRI, bone scan, and radiographic skeletal survey for lesion detection and risk stratification of Langerhans Cell Histiocytosis, Proposal for a Quantitative 18F-FDG PET/CT Metabolic Parameter to Assess the Intensity of Bone Involvement in Multiple Myeloma, Intensity harmonization techniques influence radiomics features and radiomics-based predictions in sarcoma patients, Investigation of radiomics based intra-patient inter-tumor heterogeneity and the impact of tumor subsampling strategies, Combined whole-lesion radiomic and iodine analysis for differentiation of pulmonary tumors, Radiomics Features Differentiate Between Normal and Tumoral High-Fdg Uptake, https://doi.org/10.1053/j.semnuclmed.2017.09.007, https://doi.org/10.1182/blood-2018-05-852129, https://doi.org/10.1080/10428190903040048, https://doi.org/10.1038/s41598-020-68310-w, https://doi.org/10.1016/j.ymeth.2020.05.022, https://doi.org/10.1038/nrclinonc.2017.141, https://doi.org/10.1016/j.ymeth.2020.06.020, https://doi.org/10.1038/s41598-018-37197-z, https://doi.org/10.1007/s00330-016-4470-8, https://doi.org/10.1097/RLU.0000000000002732, https://doi.org/10.1038/s41598-021-81526-8, https://doi.org/10.1038/s41598-018-31509-z, https://doi.org/10.1186/s40658-019-0244-0, https://doi.org/10.1186/s40658-020-0270-y, https://doi.org/10.1016/j.mri.2012.05.001, https://doi.org/10.1007/s00259-014-2715-9, https://pyradiomics.readthedocs.io/en/latest/features.html, https://doi.org/10.1158/0008-5472.CAN-17-0339, https://doi.org/10.1148/radiol.2020191145, https://doi.org/10.1037//0033-2909.86.2.420, https://doi.org/10.1016/j.softx.2021.100819, https://doi.org/10.1080/10428194.2020.1786555, https://doi.org/10.1148/radiol.2018172361, https://doi.org/10.1007/s00259-021-05233-2, https://doi.org/10.2967/jnumed.116.179648, https://doi.org/10.1007/s11307-017-1155-x, https://doi.org/10.1007/s11307-022-01703-7, https://doi.org/10.1038/s41598-021-03278-9, https://doi.org/10.1038/s41598-022-13967-8, http://creativecommons.org/licenses/by/4.0/. permission provided that the original article is clearly cited. Article Frood, R. et al. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate. After two cycles, the primary end point of the study was met: 93 (82.3%; 90% CI, 75.3 to 88.0) of 113 patients in the BV-AVD arm were PET-negative (Deauville score 1-3) compared with 43 (75.4%; 90% CI, 64.3% to 84.5%) of 57 in the ABVD arm. FDG-PET after two to three cycles of chemotherapy predicts progression-free and overall survival in high-grade non-Hodgkin lymphoma. The site is secure. Lue, K. H. et al. WebRisk stratification on the basis of Deauville score on PET-CT and the presence of Epstein-Barr virus DNA after completion of primary treatment for extranodal natural killer/T-cell lymphomanasal typea multicentreretrospective analysis [J]. Zhao, B. et al. For example, Mayerhoefer et al. The volume of the lesion further had to be at least 1 cm3. Younes A, Gopal AK, Smith SE, et al. FDG-PET/CT images were acquired on two different scanners: Scanner A (Gemini TF 16; Philips Medical Systems, Hamburg, Germany)19 and scanner B (Discovery MI; GE Medical Systems, Chicago, USA)20. Sci. Sci. PTCLs are heterogeneous in terms of biology, but generally have more aggressive features and poorer outcomes than aggressive B-cell lymphomas when treated with combination chemotherapy.While the best long-term results are still seen with intensive Methods: CT-based texture analysis potentially provides prognostic information complementary to interim fdg-pet for patients with hodgkins and aggressive non-hodgkins lymphomas. Long-term survival and competing causes of death in patients with early-stage Hodgkins disease treated at age 50 or younger. Before Marani C, Raiola AM, Morbelli S, Dominietto A, Ferrarazzo G, Avenoso D, Giannoni L, Varaldo R, Gualandi F, Grazia D, Lamparelli T, Bregante S, Van Lint MT, Ibatici A, Bovis F, Lemoli RM, Gobbi M, Bacigalupo A, Angelucci E. Biol Blood Marrow Transplant. Imaging Biol. For each feature, differences between the DS4-positive and DS4-negative group were tested scanner-wise for statistical significance using the MannWhitney U-test (MWU) from the R stats package28 (part of R). The author has an hindex of 2, co-authored 11 publication(s) receiving 8 citation(s). ; resources, H.A. Sci Rep 12, 20008 (2022). Skoetz N, Will A, Monsef I, Brillant C, Engert A, von Tresckow B. Cochrane Database Syst Rev. and JavaScript. Or Milgrom et al., who estimated the relapse rate of mediastinal Hodgkin Lymphoma by building a model with the five most predictive radiomic features from baseline PET scans, yielding promising AUCs13. Those with a Deauville score up to 3 were treated with an additional 2 cycles of ABVD whereas those with a positive result received 2 cycles of escalated BEACOPP plus IFRT. A metaanalysis of 18F-2-deoxy-2-fluoro-D-glucose positron emission tomography in the staging and restaging of patients with lymphoma. R package version 6.093. ; Abdelkhalek, E.R. An official website of the United States government. Careers. Google Scholar. J. Clin. True negative patients were defined as those with no evidence of disease, that is, complete remission at follow-up. Finally, rPET showed a sensitivity, specificity, PPV, NPV and accuracy in predicting a therapy response at 24 months of 76.1%, 100%, 100%, 35.3% and 78.8%, respectively, with a cut-off of 1.31 and an AUC of 0.913 (CI, Hodgkin lymphoma is the third-most-common childhood malignancy. Patients with a Deauville score of 1 to 2 were considered PET negative and randomized to either 30 Gy IFRT or no further treatment, and patients with a Deauville score of 3 to 5 underwent a fourth cycle of ABVD and IFRT. WebTailoring treatment in patients with Hodgkin lymphoma (HL) is paramount to maximize outcomes while avoiding unnecessary toxicity. Mol. The primary endpoint was freedom from progression (FFP). Bhatia, S.; Yasui, Y.; Robison, L.L. Brentuximab Vedotin with Chemotherapy for Stage III or IV Hodgkin's Lymphoma. Score 4: Uptake moderately increased compared to the liver at any site, Score 5: Uptake markedly increased compared to the liver at any site, Score X: New areas of uptake unlikely to be related to lymphoma. ; Kluge, R. FDG PET for therapy monitoring in Hodgkin and non-Hodgkin lymphomas. Revelle, W. psych: Procedures for Psychological, Psychometric, and Personality Research. 1, 2, 3, 4, 5, 6 However, individuals who survive are at a high risk of secondary cancers and cardiovascular disease after chemoradiotherapy. On scanner B, only flatness and median were selected by all methods. Therefore, this study aimed to explore if radiomic features from NECT images are linked to the metabolic activity of Hodgkin lymphoma manifestations and can discriminate between DS4-negative (DS 13) and DS4-positive (DS4 and DS5) manifestations. These two factors allow to stratify patients into three groups with divergent 2-year EFS: 89% for low-risk (51%; relapsed disease and either pretransplant DS 1-3 or DS 4-5/rMTVlow ; HR 1), 65% for intermediate-risk (28%; refractory disease and either DS 1-3 or DS 4-5/rMTVlow ; HR 3.26), and 45% for high-risk (21%; DS 4-5/rMTVhigh irrespective of disease status; HR 7.61) groups. Comprehensive investigation on controlling for ct imaging variabilities in radiomics studies. and B.H. Author disclosure: No relevant financial affiliations. Of these, 95.2% of scans scored DS 13 were kept on following or the same treatment plan was continued and patients did well. Outcome-based interpretation of early interim PET in advanced-stage Hodgkin lymphoma. National Library of Medicine A risk model for relapsed/refractory aggressive NHL integrating clinical risk factors and pretransplant Deauville score. ; validation, C.F.,H.A. ; Bartelink, H.; van Leeuwen, F.E. Computational radiomics system to decode the radiographic phenotype. Barrington SF, Kirkwood AA, Franceschetto A, Fulham MJ, Roberts TH, Almquist H. Barrington SF, Qian W, Somer EJ, Franceschetto A, Bagni B, Brun E. Itti E, Meignan M, Berriolo-Riedinger A, Biggi A, Cashen AF, Vra P. Cheson BD, Ansell S, Schwartz L, Gordon LI, Advani R, Jacene HA. To achieve reproducible results, we determined the final DS using the qPET approach23. (This article belongs to the Special Issue, Tailoring treatment in patients with Hodgkin lymphoma (HL) is paramount to maximize outcomes while avoiding unnecessary toxicity. PubMed Central A Feature Research reported in this article was supported by the National Institute of General Medical Sciences of the National Institutes of Health under award number 5U54GM104942-03. WebIn addition, Hodgkin lymphoma study groups of adults use a threshold of erythrocyte sedimentation rate of more than 50 mm in the first hour in patients without B symptoms and an erythrocyte sedimentation rate of more than 30 mm in the first hour in those with B symptoms as a risk factor. Flechsig et al. 2020 Nov 24;4(22):5762-5771. doi: 10.1182/bloodadvances.2020002814. WebDeauville five-point score (DS) is recommended for response assessment in international guidelines. ; Krasin, M.J.; Ness, K.K. Published by Wolters Kluwer -. Journal of Personalized Medicine. Deauville five-point score (DS) is recommended for response assessment in international guidelines. ; Bernardo, M.P. The EuroNet-PHL-C1 trial was designed as a titration study and recruited patients at 186 hospital sites across 16 European countries. Ilivitzki, A.; Radan, L.; Ben-Arush, M.; Israel, O.; Ben-Barak, A. Routine vaccinations recommended by the Centers for Disease Control and Prevention (CDC) should resume, including any recommended inactivated or live vaccines three months after chemotherapy or six months after antiB-cell antibody therapy.43,45 Patients receiving a hematopoietic stem cell transplant should receive a series of three doses of Haemophilus influenzae type b vaccine starting six to 12 months after a successful transplant. ; methodology, S.N.N., J.M.M.R., I.G.S. investigated a lymph node/aorta density ratio in patients with non-small cell lung cancer undergoing preoperative 18F-FDG-PET/CT, pointing out a correlation between lymph node metastases and lymph node density40. Blautzik, J.; Grelich, L.; Schramm, N.; Henkel, R.; Bartenstein, P.; Pfluger, T. What and how should we measure in paediatric oncology FDG-PET/CT? Prognostic value of pretreatment radiomic features of 18F-FDG PET in patients with hodgkin lymphoma. Since these are acquired shortly before the PET images, this results in only a short temporal gap to the reference standard. Among the scans that showed discordance, 24 scans scored DS 4/5 were continued on the same treatment regimen and the next assessment showed disease progression. In a multivariable analysis, we identified two independent factors predicting treatment failure: pretransplant DS combined with rMTV41% and disease status (primary refractory vs. relapsed). The most common subtype, diffuse large B-cell lymphoma, has a 40% lifetime relapse rate.37 Lifetime relapse in Hodgkin lymphoma occurs in 10% to 15% of patients with early stage disease and 40% of patients with advanced stage disease.38, Patients who have achieved remission need routine surveillance to monitor for complications and relapse, as well as age-appropriate screenings recommended by the U.S. Preventive Services Task Force.39 Complications of lymphoma treatment include secondary malignancies (e.g., breast, lung, skin, colon), cardiac disease, infertility, and endocrine, neurologic, and psychiatric dysfunctions. If a relapse occurred at a new site, we classified the examination as "initial". PMC and T.E. Julie Faudemer, Nicolas Aide, Charline Lasnon, Queralt Martn-Saladich, Gabriel Reyns-Llompart, Montse Corts-Romera, Sarah A. Milgrom, Hesham Elhalawani, Grace L. Smith, Jeong Rye Kim, Hee Mang Yoon, Jin Seong Lee, Maria E. S. Takahashi, Camila Mosci, Celso D. Ramos, Amandine Cromb, Michle Kind, Olivier Saut, Lea Azour, Jane P. Ko, William H. Moore. Patient information: See related handout on lymphoma, written by the authors of this article. The physician should focus on shared decision-making when discussing treatment options with all patients, but particularly for those older than 60 years, including whether the patient should pursue treatment.25, The standard treatment for Hodgkin lymphoma is ABVD (doxorubicin [Adriamycin], bleomycin, vinblastine [Velban], and dacarbazine), but other regimens such as the Stanford V (doxorubicin, vinblastine, mechlorethamine, etoposide [Toposar], vincristine, bleomycin, and prednisone) and escalated-BEACOPP (bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine [Matulane], and prednisone) can be used.2428 Treatment for non-Hodgkin lymphoma varies depending on the histology, but often uses treatments such as CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) with or without rituximab (Rituxan; R-CHOP), a monoclonal antibody specific for CD20-positive B lymphocytes.29 Other medications such as bendamustine (Bendeka), an alkylating agent, and lenalidomide (Revlimid) are also used in many non-Hodgkin lymphoma treatments.30,31 Common complications of these therapies are listed in Table 5.2527,2936. Considering the results of the MWU test, 41 features from the dataset of scanner A and eight from the dataset of scanner B showed a significant difference between DS4-positive and DS4-negative lesions. and I.G.S. Positron emission tomography-computed tomography standardized uptake values in clinical practice and assessing response to therapy. https://doi.org/10.1016/j.ymeth.2020.05.022 (2021). Baseline SUV, When using a cut-off of 15.5 g/mL, baseline SUV. 41, 121904. https://doi.org/10.1118/1.4900821 (2014). Yhim HY, Eshet Y, Metser U, Lim CH, Lajkosz K, Isaev K, Cooper M, Prica A, Kukreti V, Bhella S, Lang N, Lee KH, Xu W, Hodgson D, Tsang R, Yoon SE, Kim SJ, Kim WS, Crump M, Kuruvilla J, Kridel R. Blood Adv. CAS Radiology 288, 407415. Google Scholar. Get what matters in cancer research, free to your inbox weekly. EJNMMI Phys. Classic Hodgkin lymphoma (cHL) includes the following histologic subtypes: nodular sclerosis cHL, lymphocyte-rich cHL, mixed cellularity cHL, and Lymphoma 61, 29232930. Epub 2018 Jul 21. Google Scholar. Med. From these segmentations, 107 features were extracted with PyRadiomics. ; data curation, S.N.N., L.J.J., J.R., I.G.S. PET-positive suture granuloma of abdominal wall 56 years post-appendicectomy mimicking recurrence of For this, we considered the readings from S.N.N. ; Klokman, W.J. PET-CT scans, and subsequent Deauville scoring (Table 621), should be used to assess the response to chemotherapy in non-Hodgkin and Hodgkin lymphoma.25,30,31,33 A score of 3 or less is considered complete remission in non-Hodgkin lymphoma and should conclude the current treatment course. Nodal Pathologic Complete Response Rates in Luminal Breast Cancer Vary by Genomic Risk. Paediatric and adolescent Hodgkin lymphoma: Information derived from diffuse organ uptake of 18F-fluorodeoxyglucose pre-treatment and on interim PET/CT. Exp Hematol Oncol. https://doi.org/10.1007/s00259-014-2715-9 (2014). Kursa, M. B. Praznik: High performance information-based feature selection. Ganeshan, B. et al. Raanani P, Shasha Y, Perry C, Metser U, Naparstek E, Apter S. Schaefer NG, Hany TF, Taverna C, Seifert B, Stumpe KD, von Schulthess GK. PET data from scanner B were reconstructed iteratively with Bayesian penalized likelihood reconstruction (GE Q.Clear) with a penalization factor of 450, which included time of flight analysis and point spread function modeling21. Post-therapy DS showed a sensitivity, specificity, PPV, NPV and accuracy of 66.7%, 97.8%, 95.7%, 80% and 94.2%, repsectively. Interestingly, even in NECT images, the feature median that ultimately describes the density of a lymphoma manifestation differentiated between DS4-positive and DS4-negative lesions, thereby showing constantly higher values in DS4-positive manifestations (numerical results of the radiomics analysis are provided in the supplementary Table S3; S3a for scanner A and S3b for scanner B). Department of Nuclear Medicine and PET-CT, Burjeel Medical City, Abu Dhabi 92510, United Arab Emirates, Academic Radiology, Department of Translational Research, University of Pisa, 56126 Pisa, Italy, Amrita Institute of Medical Sciences, Kochi 682041, Kerala, India, Department of Nuclear Medicine, VPS Lakeshore Hospital, Kochi 682040, Kerala, India. Bhakta, N.; Liu, Q.; Yeo, F.; Baassiri, M.; Ehrhardt, M.J.; Srivastava, D.K. Ger, R. B. et al. 2023 Standard of Care. Copyright 2020 by the American Academy of Family Physicians. Clipboard, Search History, and several other advanced features are temporarily unavailable. Your email address will not be published. Four patients were PET positive at the end of ABVD ISSN 2045-2322 (online). The https:// ensures that you are connecting to the Help us to further improve by taking part in this short 5 minute survey, Prognostic Value of Soluble AXL in Serum from Heart Failure Patients with Preserved and Reduced Left Ventricular Ejection Fraction, Intrapartum Factors Affecting Abnormal Lipid Profiles in Early Postpartum Period, Radiomics in Lung Metastases: A Systematic Review, positron emission tomography computed tomography (PET-CT), https://www.ibm.com/products/spss-statistics, https://creativecommons.org/licenses/by/4.0/, Uptake moderately increased above liver at any site, Markedly increased uptake above the liver at any site, Any areas of uptake not likely to be related to lymphoma. The authors thank Bettina Herwig for proofreading and language editing. Jha, A. K. et al. BMC Bioinf. https://doi.org/10.1038/nrclinonc.2017.141 (2017). ; Alpert, N.M. FDG-PET in oncology: Theres more to it than looking at pictures. The datasets generated and/or analyzed during the current study are not publicly available due to an IRB decision which was made in the interest of ensuring patient confidentiality but are available from the corresponding author on reasonable request. 2018 Dec;24(12):2501-2508. doi: 10.1016/j.bbmt.2018.07.025. Mol. Increased x-ray attenuation in malignant vs. benign mediastinal nodes in an orthotopic model of lung cancer. Magn. Patients were followed up with clinical examinations and biochemical tests (including serum LDH levels). ; Erdrich, A.S.; Hundsdoerfer, P.; Ruf, J.; Henze, G.; Schnberger, S.; Amthauer, H.; Hautzel, H. Explorative analyses on the value of interim PET for prediction of response in pediatric and adolescent non-Hodgkin lymphoma patients.
deauville score hodgkin lymphoma
o que você achou deste conteúdo? Conte nos comentários.